Sporotrichosis

Sporotrichosis, a fungal infection instigated by the pathogen Sporothrix species, is attributed to the dimorphic fungus Sporothrix schenckii. Distinguishing itself in the realm of uncommon diseases like sporotrichosis, our company excels by providing all-encompassing, specialized services designed for researchers and scientists involved in this unique field.

Overview of Sporotrichosis

Sporotrichosis is mainly a type of subcutaneous mycosis, impacting the skin, subcutaneous tissue, and lymphatic system. The usual mode of transmission involves the accidental introduction of the fungus into the skin through trauma, frequently from coming into contact with tainted plant matter or soil. Moreover, acquiring this infection through scratches or bites from infected animals is another common avenue. Sporotrichosis presents in two primary forms: cutaneous sporotrichosis and extracutaneous sporotrichosis.

Fig.1 Phylogenetic analysis of the main members of medical relevance in the genus Sporothrix. (Rodrigues, A. M., et al., 2022)

Pathogenesis of Sporotrichosis

Sporotrichosis, a fungal infection primarily triggered by the dimorphic fungus Sporothrix schenckii and its related species, is prevalent in vegetation worldwide, decaying organic material, Sphagnum moss, and soil. This fungus infiltrates the body through skin breaks, often resulting in a minor, painless bump at the entry point. The infection can progress along the lymphatic vessels, causing a series of nodules or ulcers. In certain instances, particularly in individuals with weakened immune systems, the infection may disseminate to other organs like bones, joints, and lungs.

Fig.2 The main antifungal agents and their cellular targets. (Rodrigues, A. M., et al., 2022)

Vaccine and Therapeutic Development for Sporotrichosis

Our Services

Our company has advanced infectious disease models, and vaccine and therapeutic development platforms, and excels in providing a seamless service for professionals seeking to delve into the intricacies of rare diseases. From access to cutting-edge laboratory facilities to expert consultation services, we ensure that researchers have all the necessary tools at their disposal to advance their studies on diseases like sporotrichosis.

Featured Services for Sporotrichosis

Vaccine Development

• Live-attenuated Vaccine
• Inactivated Vaccine
• Toxoid Vaccine
• Viral Vector Vaccine
• Virus-like Particles Vaccine
• Protein Subunit Vaccine
• mRNA Vaccine
• DNA Vaccine

Therapeutic Development

• Small Molecule Drug Development Services
• Therapeutic mRNA Development Services
• Therapeutic Antibody Development Services
• Cell Therapy Development Services

Infectious Disease Models

• Systemic and peritoneal models of sporotrichosis in mice
• Subcutaneous model of sporotrichosis in mice
• Galleria mellonella model of Sporothrix schenckii infection
• Others

By offering a centralized hub of resources and expertise, we empower researchers and scientists to make significant strides in understanding and combating diseases such as sporotrichosis. If you are interested in availing of our services, please do not hesitate to reach out to us for more details and quotations related to our offerings.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.