Pathogen infection models are indispensable for investigating disease progression, understanding host-pathogen interactions, and advancing the development of innovative therapeutics. At our company, we have a steadfast commitment to the development of pathogen infection models. We employ cutting-edge techniques and rigorous methodologies to create highly relevant and reliable models that accurately recapitulate the complexities of infectious diseases.
Overview of Pathogen Infection Models
Pathogen infection models are animal models specifically designed to mimic and study the progression of infectious diseases in humans. These models involve the deliberate introduction of pathogens into animals, providing a controlled experimental system for infectious disease research. The following are applications of pathogen infection models.
- Infectious disease mechanism research
- Disease progression research
- Drug target discovery and identification
- Pathogen-host interaction research
- Immune response research
- Safety and efficacy evaluation of potential therapies
Fig. 1 Hemorrhagic fever virus infection models and important immunological considerations. (Warner B M., 2021)
Pathogen Infection Models for Infectious Diseases
Pathogen infection models are extensively utilized in the study of infectious disease pathogenesis, prevention, and treatment. The following is a list of some pathogen infection models for infectious diseases.
| Diseases |
Pathogen |
Species |
Infection Method |
Applications |
| Salmonellosis |
Salmonella |
Mice |
Oral inoculation |
Study gastrointestinal colonization, systemic dissemination, immune responses, and the efficacy of antibiotics or vaccines against Salmonella |
| Lyme Disease |
Borrelia burgdorferi |
Mice |
Tick-bite inoculation |
Study disease progression, host immune responses, tissue tropism, and the evaluation of therapeutic interventions |
| Pneumococcal Pneumonia |
Streptococcus pneumoniae |
Rats |
Intranasal instillation |
Study the development of pneumonia, host immune responses, bacterial dissemination, and the efficacy of antimicrobial treatments or vaccines |
| Dengue Fever |
Dengue virus |
Rhesus macaques |
Intravenous injection of virus |
Study viral replication, immune responses, disease progression, and the evaluation of antiviral drugs or vaccine candidates |
Our Services
Our company is at the forefront of animal model development, utilizing advanced technologies and rigorous development processes to create robust and reliable pathogen infection models. These models are invaluable tools in infectious disease research, enabling you to study disease mechanisms, evaluate potential interventions, and develop preventive strategies.
Animal Species Selection
Taking into account factors such as human genetic similarity, physiological relevance, susceptibility to pathogens, availability, cost, and ethical considerations, we select the most suitable species for developing pathogen infection models specific to particular infectious diseases.
Acquisition of Pathogen
Our scientists will obtain clinical isolates, reference strains or genetically modified variants of the pathogen and ensure the virulence of the pathogen and the ability to replicate in the chosen animal species.
Infection Method Development
Our researchers design and optimize the infection method to replicate the natural route of transmission and disease progression. This may involve techniques such as aerosol inhalation, oral inoculation, intravenous injection, intranasal instillation, or tick-bite inoculation, among others.
Model Validation and Comparison
We evaluate the infection dynamics, disease severity, immune responses, and other relevant outcomes of the constructed animal model. The infection model is validated by comparing the observed outcomes and responses with known characteristics of the target disease in humans.
Model Optimization
Based on the validation results, we can timely understand the limitations and deficiencies of the model. We will further improve or modify the model to meet specific research needs.
Optional Species
- Rodents: mice, rats, guinea pigs, rabbits, etc.
- Large Animals: pigs, dogs, sheep, cows, ferrets, etc.
- Fish and Insects: zebrafish, medaka, fruit flies, etc.
- Non-human Primates: rhesus macaques, cynomolgus macaques, African green monkeys, etc.
Our company develops pathogen infection models for a variety of infectious diseases, including bacterial infections, viral infections, parasitic infections, fungal infections, and prion diseases. These models can be used for preclinical studies of infectious disease therapeutics, including pharmacodynamics, pharmacokinetics, and drug safety assessments.
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Warner B M. Pathogen dose in animal models of Hemorrhagic fever virus infections and the potential impact on studies of the immune response[J]. Pathogens, 2021, 10(3): 275.
- Swearengen J R. Choosing the right animal model for infectious disease research[J]. Animal models and experimental medicine, 2018, 1(2): 100-108.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
