Parasitic infections refer to illnesses or conditions caused by parasites that live and reproduce within your body. These parasites are organisms that rely on a host to obtain the nutrients necessary for their survival. At our company, we are at the forefront of vaccine development services, employing cutting-edge technologies and expertise to combat parasitic infections.
Introduction to Parasitic Infections
Parasitic infections are a global health concern, affecting millions of people, particularly in developing countries. They are caused by various parasites, including protozoa, helminths, and ectoparasites, which can be transmitted through contaminated water, food, soil, or direct contact with infected individuals. Recent literature highlights the significant morbidity and mortality associated with parasitic diseases, emphasizing the urgent need for improved diagnostic methods and effective treatment.
Diagnosis Development of Parasitic Infections
| Diagnostic Method |
Description |
Examples |
| Microscopy |
Examination of biological samples using light or fluorescent microscopes to identify morphological features of parasites. |
Detection of trophozoites of Entamoeba histolytica, Giardia duodenalis, and Balantidium coli. |
| Point-of-Care Testing (POCT) |
Tests performed at or near the site of patient care, offering quick and user-friendly diagnostic results without needing complex lab equipment. |
Used for diagnosing malaria, visceral leishmaniasis, and other parasitic infections. |
| Lateral Flow Immunochromatographic Assays (LFIA) |
Simple, quick, and cost-effective tests where a liquid sample migrates through a membrane to identify the presence of specific biomarkers. |
Rida Quick Cryptosporidium/Giardia/Entamoeba Combi kit, immunochromatographic assays for visceral leishmaniasis. |
| Multiplex Molecular Detection Assays |
Simultaneous detection of multiple pathogens using multiplex qPCR technology, allowing differentiation of species and detection of resistance genes. |
Multiplex qPCR for detection of Plasmodium species, gastrointestinal multiplex molecular panels. |
Targets Discovery for Parasitic Infections
A significant advancement in antimalarial drug development is the shift towards cell-based phenotypic screening. Recent studies have utilized omics approaches to identify new targets for interventions against protozoan parasites, demonstrating the considerable advantages of using diverse omics techniques in drug discovery to identify promising drug targets against these pathogens.
- Omics-based Methods: They include genomics, proteomics, transcriptomics, and epigenomics. Enable the discovery of critical pathways and essential genes that can be targeted for therapeutic intervention.
- Phenotypic Screening: It involves screening large libraries of compounds against live parasites to identify those that have a desired effect, such as killing the parasite or inhibiting its growth.
- Structure-guided Drug Discovery: This technique uses the three-dimensional structures of target proteins to design and optimize small molecules that can specifically bind to and inhibit these targets.
- Chemoproteomics: This approach uses chemical probes to identify the proteins that interact with a drug within the parasite. It helps to elucidate the drug's mechanism of action.
Fig.1 Overview of the antimalarial target discovery and drug discovery processes. (Cowell, A.N. and Winzeler, E.A., 2019)
Our Services
The development of therapies and vaccines for parasitic infections is an intricate and rigorous process that requires scientific expertise, regulatory compliance, and extensive testing. Our company specializes in providing comprehensive therapy and vaccine development services, tailored to address the unique challenges posed by different pathogens.
Types of Parasitic Infections
| A |
B |
C |
D-F |
- African Trypanosomiasis
- Amoebiasis
- Angiostrongyliasis
- Anisakiasis
- Ascariasis
|
- Babesiosis
- Balantidiasis
- Baylisascaris Infection
- Blastocystosis
|
- Capillariasis
- Clonorchiasis
- Cryptosporidiosis
- Cutaneous Larva Migrans (CLM)
|
- Dientamoebiasis
- Diphyllobothriasis Echinococcosis
- Fasciolasis
- Fasciolopsiasis
- Filariasis
|
| G-I |
L-M |
P-S |
T |
- Giardiasis
- Gnathostomiasis
- Hookworm Infection
- Hymenolepiasis
- Isosporiasis
|
- Leishmaniasis
- Lymphatic Filariasis
- Malaria
- Metagonimiasis
- Microsporidiosis
- Myiasis
|
- Pinworm Infection
- Primary Amoebic Meningoencephalitis (PAM)
- Strongyloidiasis
|
- Taeniasis
- Toxoplasmosis
- Trichinosis
- Trichomoniasis
|
Why Choose Us?
The field of therapeutic approaches for parasitic infections is continually advancing, with new technologies presenting promising opportunities for innovation and enhancement. At our company, we leverage these advancements to improve the effectiveness and accessibility of vaccines. If our extensive array of services interests you, we strongly encourage you to contact us without hesitation.
References
- Cowell, A.N. and Winzeler, E.A., "Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections." Genome Med, (2019). 11(1): p. 63.
- Kian, M., et al., "Efficacy of Mesenchymal Stem Cells Therapy in Parasitic Infections: Are Anti-parasitic Drugs Combined with MSCs More Effective?" Acta Parasitol, (2022). 67(4): p. 1487-1499.
- Momcilovic, S., et al., "Rapid diagnosis of parasitic diseases: current scenario and future needs." Clin Microbiol Infect, (2019). 25(3): p. 290-309.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
