mRNA vaccines offer distinct advantages over traditional vaccines, and our company is fully committed to providing top-notch services for mRNA vaccine development. Partnering with us grants you access to cutting-edge platforms that will expedite your vaccine research and facilitate the path to commercialization.
Introduction to mRNA Vaccines
mRNA vaccines harness the power of messenger RNA (mRNA) to stimulate the immune system. In contrast to conventional vaccines, which rely on weakened or inactivated forms of pathogens, mRNA vaccines take advantage of a short segment of mRNA that encodes a specific viral protein. This mRNA is introduced into the body, guiding cells to produce the viral protein and prompting an immune response.
Fig. 1 Mechanism of immune activation by mRNA-LNPs vaccines. (Al Fayez N, et al., 2023)
How Do mRNA Vaccines Work?
The mechanism of action of mRNA vaccines can be summarized in several key steps.
| Step |
Description |
| Cellular Uptake and Protein Production |
After the vaccine is administered, mRNA molecules are taken up by cells. Cellular machinery recognizes the introduced mRNA and begins the process of translating it into viral proteins. |
| Antigen Presentation |
The newly generated viral protein is presented on the surface of cells, acting as a signal to the immune system that a foreign protein from a pathogen is detected. |
| Immune Response Activation |
Foreign proteins stimulate an immune response and activate B cells and T cells. T cells help coordinate and enhance the immune response. B cells produce antibodies against viral proteins. |
| Memory Cell Formation |
mRNA vaccines also stimulate the formation of memory B cells and memory T cells. These specialized cells retain a memory of the viral protein, enabling a quick and powerful immune response in case the individual encounters the actual virus in the future. |
Application of mRNA Vaccines in Infectious Disease Prevention
mRNA vaccines have emerged as a powerful tool in the prevention of infectious diseases. Their unique characteristics and mechanism of action make them versatile and promising candidates for combating a wide range of pathogens. Several approved mRNA vaccines are listed below.
Pfizer-BioNTech vaccine
The Pfizer-BioNTech vaccine is an approved and typical mRNA vaccine. This vaccine utilizes messenger RNA (mRNA) to encode the spike protein found on the surface of the SARS-CoV-2 virus. After administration, the mRNA instructs cells to produce the spike protein, triggering an immune response to prevent COVID-19.
Moderna vaccine
The Moderna vaccine is another typical mRNA vaccine developed by Moderna, Inc. It has been approved for the prevention of COVID-19. Similar to the Pfizer-BioNTech vaccine, the Moderna vaccine utilizes mRNA to encode the spike protein of the SARS-CoV-2 virus, stimulating the body to generate an immune response.
Our Services
mRNA vaccines have revolutionized the field of infectious disease prevention, and our company is at the forefront of mRNA vaccine development and research. We are proud to offer comprehensive and top-quality services to support you in achieving the commercialization of mRNA vaccines.
- Development Workflow of mRNA Vaccines
Optional Infectious Diseases
- Coronavirus Disease 2019 (COVID-19)
- Respiratory Syncytial Virus (RSV)
- Zika Virus
- Ebola Virus
- Dengue Virus
- Human immunodeficiency virus (HIV)
- Malaria
- Tuberculosis (TB)
- Influenza
- And More
Our company has been actively involved in the development and research of mRNA vaccines. If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Al Fayez N, Nassar M S, Alshehri A A, et al. Recent advancement in mRNA vaccine development and applications[J]. Pharmaceutics, 2023, 15(7): 1972.
- Pardi N, Hogan M J, Weissman D. Recent advances in mRNA vaccine technology[J]. Current opinion in immunology, 2020, 65: 14-20.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
