Infectious diseases continue to pose significant threats to global health, requiring effective drug discovery and development strategies. To address this critical need, our company has established itself as a leader in providing infectious disease model development services.
Model Development in Infectious Diseases
Infectious disease model development involves the creation of accurate and representative models that mimic the complexities of human infections. These models serve as invaluable tools for understanding disease mechanisms, evaluating the efficacy and safety of potential therapeutic interventions, and accelerating the drug development process. By utilizing various bioengineering techniques, such as animal models, primary cell culture, organoids, organ-on-a-chip systems, and in vitro tissue cultures, scientists can create disease models that closely resemble human physiology and pathophysiology.
Fig.1 Common types of disease models. (Sajjad H., et al., 2021)
Types of Infectious Disease Models
Cell-based Models
Cell-based models typically involve the cultivation of specific cell types that are susceptible to the infectious agent. These models provide a controlled environment to investigate the mechanisms of infection, host immune responses, and the evaluation of potential antiviral or antibacterial compounds.
Organoid Models
Organoids are three-dimensional structures derived from stem cells or tissue-specific progenitor cells, which can self-organize and differentiate into various cell types found in specific organs. They accurately mimic the complexity and functionality of human tissues and organs.
Animal Models
Rodents, such as mice and rats, are commonly used due to their genetic similarity to humans and the availability of well-established genetic tools. By infecting animals with pathogens, researchers can study disease progression, immune responses, and evaluate the efficacy of potential therapies.
Our Services
At Our Company, we are committed to revolutionizing infectious disease drug discovery and development through our exceptional infectious disease model development services. By leveraging our expertise and state-of-the-art technologies, we offer a diverse range of services to accelerate the identification and evaluation of potential therapeutics.
Types of Infectious Diseases
Animal Model Development
- Pathogen Infection Model Development
- Genetically Engineering Model Development
- Humanized Model Development
- Customized Animal Model Development
In Vitro Model Development
- Cell-based Model
-Cell line development
-Primary cell development
-iPSC development
- Organoid Model
-Adult stem cell (ASC) source
-Embryonic stem cell (ESC) source
-Patient-derived organoid (POD)
Our team of highly skilled scientists and engineers is experienced in developing bioengineered disease models that closely mimic human infectious diseases. Through careful selection and optimization of culture conditions, we ensure the representation of relevant disease features, including histological similarity, gene regulation patterns, and known drug responses. If our comprehensive suite of services has piqued your interest, we earnestly encourage you to reach out to us without any reservations.
References
- Sajjad H., et al. "Cancer models in preclinical research: A chronicle review of advancement in effective cancer research." Animal Models and Experimental Medicine 4.2 (2021): 87-103.
- Loewa Anna, James J. Feng, and Sarah Hedtrich. "Human disease models in drug development." Nature reviews bioengineering 1.8 (2023): 545-559.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
