Humanized Model Development

Humanized models have become a critical tool in infectious disease research. Our commitment to delivering high-quality humanized models extends to collaborating with researchers, academic institutions, and pharmaceutical companies. We work closely with our partners to customize models according to specific research needs, ensuring that they are reliable, reproducible, and tailored to address their unique scientific questions.

Introduction to Humanized Models

Humanized models refer to experimental systems where animals are genetically modified or transplanted with human cells, tissues, or genes to mimic specific aspects of human physiology or pathology. These models are designed to closely resemble certain characteristics of human biology, such as immune responses, disease susceptibility, or organ function, in order to study human diseases and test potential treatments in a more relevant context.

Fig. 1 Humanized mouse models of Epstein-Barr virus (EBV) infection. (Fujiwara S, et al., 2015)

Application of Humanized Models in Infectious Disease Research

Humanized models have been extensively applied in infectious disease research to study the pathogenesis of human-specific pathogens, evaluate vaccine candidates, test antiviral therapies, and understand host immune responses. These models provide a valuable platform for investigating the complex interactions between pathogens and the human immune system, allowing researchers to gain insights into disease progression and develop effective interventions.

Our Services

Humanized model development plays a vital role in improving our understanding of infectious diseases and accelerating the translation of research results into clinical applications. Using advanced technologies such as CRISPR/Cas9 gene editing, stem cell research, and tissue engineering, our company develops humanized models with enhanced human-like characteristics. We follow a rigorous development process to ensure the reliability and reproducibility of humanized models.

Humanized Model Development Process

Drug Target Identification

Hit Discovery

Lead Optimization

Antipathogen Activity Evaluation

Preclinical Studies

Formulation Development

Optional Species

Our company develops humanized models for a variety of infectious diseases, including bacterial infections, viral infections, parasitic infections, fungal infections, and prion diseases. These models closely mimic human physiology and disease traits, offering optimal experimental platforms for preclinical studies into infectious disease therapeutics , encompassing pharmacodynamics, pharmacokinetics, and drug safety assessments.

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.