Genetically Engineering Model Development

Genetically engineering models are indispensable in the study of disease progression, the identification of potential therapeutic targets, and the advancement of innovative treatments. At our company, we have a strong dedication to the development of genetically engineering models. We employ state-of-the-art technologies and rigorous methodologies to create highly relevant and dependable models that faithfully capture the intricacies of infectious diseases.

What is a Genetically Engineering Model?

Genetically engineering models (GEMs) are animal models in which specific genetic alterations have been introduced to mimic human diseases and conditions. These alterations include gene knock-out, knock-in, overexpression, conditional gene expression, etc. GEMs serve as powerful tools for studying the underlying mechanisms of diseases, identifying potential therapeutic targets, and evaluating the efficacy and safety of novel drugs.

Fig. 1 Rat model constructed using CRISPR-Cas9. (Warner B M., 2021)

Genetically Engineering Models for Infectious Diseases

The global market size for genetically engineering models (GEMs) and services was $3.1991 billion in 2022. It is projected to reach $5.88155 billion by 2032, with a compound annual growth rate of 7.0% during the forecast period. Among them, GEMs for infectious diseases hold a significant share. The table below presents some GEMs for infectious diseases.

Our Services

Our company is leading the way in the development of genetically engineered models for infectious diseases. We utilize cutting-edge technologies and follow stringent development processes to ensure the creation of robust and dependable genetically engineering models.

Workflow of Genetically Engineering Model Development

Target Gene Identification

Our scientists identify target genes that play key roles in disease development, progression or host response through extensive research and experimental validation.

Technology Selection

Select appropriate genetic engineering technology based on efficiency, accuracy and compatibility with target tissues, such as CRISPR-Cas9, TALENs, transgenic technology, etc.

Gene Modification

Next, we introduce the desired genetic modification into embryonic stem cells or fertilized eggs of animal models. This may involve gene knock-out, knock-in, point mutation, or other modifications.

Validation and Application

The GEMs are extensively validated to ensure their reliability and reproducibility. These models are then employed for drug screening, target identification, mechanism elucidation, preclinical studies, etc.

Phenotypic Characterization

The established GEMs are fully characterized to assess the phenotypic effects of the genetic alterations. This includes assessment of disease manifestations, molecular pathways, immune responses, etc.

Model Generation

We implant genetically modified embryonic stem cells or fertilized eggs into surrogate mothers and identify and breed offspring carrying the desired genetic modification to establish stable GEM lines.

Optional Types of Animal Models

Optional Species

• Rodents: mice, rats, guinea pigs, rabbits, etc.
• Large Animals: pigs, dogs, sheep, cows, etc.
• Fish and Insects: zebrafish, fruit flies, mosquitoes, etc.
• Non-human Primates: rhesus macaques, cynomolgus macaques, marmosets, etc.

Our company develops genetically engineering models for a variety of infectious diseases, including bacterial infections, viral infections, parasitic infections, fungal infections, and prion diseases. These models can be used for preclinical studies of infectious disease therapeutics, including pharmacodynamics, pharmacokinetics, and drug safety assessments.

If you are interested in our services, please feel free to contact us for more details and quotation information of related services.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.