Fungal infections, also known as mycoses, are caused by various types of fungi and can affect different parts of the body. These infections are a significant global health concern, impacting over one billion individuals annually. Our company is a leader in the field of infectious diseases, specializing in comprehensive services for researchers and scientists in the industry, particularly in the area of fungal infections.
Overview of Fungal Infections
Fungi are omnipresent, inhabiting diverse environments such as soil, plants, and animals. Despite there being an estimated 6 million fungal species worldwide, only a small fraction (less than 600) is pathogenic to humans. While many fungi are harmless, certain varieties can lead to infections in humans, particularly in cases of compromised immunity or fungal overgrowth. Fungal infections can manifest in varying degrees, ranging from mild surface-level conditions to severe systemic diseases that pose life-threatening risks.
Fig.1 Common modes of entry for pathogens. (Otto, W. R., et al., 2020)
Pathogenesis of Fungal Infections
The development of fungal infections involves intricate interactions between the host's immune system and the invading fungi. Key stages in the pathogenesis of these infections include fungal entry, colonization, evasion of immune responses, tissue invasion, and subsequent host reactions. Fungal infections are typically categorized based on the depth of tissue involvement, with distinctions made among superficial, cutaneous, and systemic infections.
Fig.2 Signaling pathways of fungal recognition. (Loh, J. T., et al., 2023)
Diagnostics Development of Fungal Infections
The evolution of diagnostic technologies has vastly improved the accuracy and timeliness of fungal infection detection. Here are some notable diagnostic technologies and methods:
Molecular tests
Polymerase chain reaction (PCR) and other molecular techniques allow for the detection of fungal DNA or specific genetic markers in samples, providing rapid and precise identification of fungal pathogens.
Serological tests
Serological tests utilizing methods like enzyme-linked immunosorbent assays (ELISAs) have streamlined the detection of specific antibodies or antigens in samples, enhancing the diagnostic accuracy of fungal infections.
Genetic tests
Next-generation sequencing (NGS) technologies have emerged as a powerful tool for identifying genetic factors and pathogenicity, paving the way for targeted therapeutic interventions and personalized therapeutic strategies.
Vaccine and Therapeutics Development of Fungal Infections
| Therapeutics Types |
Names |
Mechanism of Action |
Research Phase |
| Vaccine |
NDV-3A |
Elicit antibody responses that attenuate C. albicans virulence |
Phase II trials |
| PEV7 |
Generate specific IgG and IgA antibodies for protection against vaginal candidiasis |
Phase I trials |
| Inhibitor |
F901318 |
Selective inhibition of the DHODH |
Phase II trials |
| Cytokine |
TNFα |
Enhance immune response |
Preclinical research |
| Antibody |
Mycograb |
Targeting fungal heat shock protein 90 |
Phase III trials |
| Cell therapy |
Adoptive T-cell therapy |
Restore cellular immunity |
Preclinical research |
| CAR T-cell therapy |
Secrete IFNγ to fight fungal infections |
Preclinical research |
Our Services
Our company boasts a team of highly skilled and experienced experts, who focus on personalized guidance and services, we offer a comprehensive range of solutions including pathogen and host research, diagnostics development, vaccine development, therapeutic development, infectious disease model development, and preclinical research.
Types of Fungal Infections
Therapeutic Development Services of Fungal Infections
Vaccine Development of Fungal Infections
Animal Models Development of Fungal Infections
Animal models of fungal infections play a crucial role in studying the pathogenesis, host immune response, and evaluating potential therapeutics for fungal infections. Our company offers a variety of animal models of fungal infections to help you explore disease mechanisms, evaluate therapeutic interventions, and gain insights into host-pathogen interactions in fungal infections.
| Types of Model Development |
Routes of Infection |
Animal Species |
| Pathogen infection model, genetically engineering model, humanized model development. |
Intravenous, intraperitoneal, intranasal, intratracheal, or subcutaneous inoculation, etc. |
Mice, rats, rabbits, guinea pigs, hamsters, dogs, cats, toads, bats, and birds, etc. |
Our commitment to delivering high-quality services and being a reliable partner in the infectious disease industry underscores our dedication to facilitating research and innovation. For inquiries about our services or quotations, please feel free to contact us for further information and assistance.
References
- Loh, Jia Tong, et al. "Fungal infections: Immune defense, immunotherapies and vaccines." Advanced drug delivery reviews 196 (2023): 114775.
- Mendonça, Alexandre et al. "Fungal infections diagnosis - Past, present and future." Research in microbiology 173.3 (2022): 103915.
- Jensen, Henrik Elvang. "Animal models of invasive mycoses." APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 130.7 (2022): 427-435.
- Otto, William R, et al. "Fungal infections in children with haematologic malignancies and stem cell transplant recipients." British journal of haematology 189.4 (2020): 607-624.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
