Blastomycosis, a severe fungal disease affecting humans and other mammals, is caused by environmentally acquired infection with thermally dimorphic fungi from the Blastomyces genus. Our company excels in the field of blastomycosis by offering comprehensive services that cater to the needs of researchers and scientists.
Overview of Blastomycosis
Blastomycosis is a serious fungal infection caused by the dimorphic fungus Blastomyces dermatitidis. The genetic and geographic diversity of these pathogens is now recognized to be more extensive than previously thought. Besides Blastomyces dermatitidis and the cryptic species Blastomyces gilchristii responsible for blastomycosis in certain regions of North America, atypical cases can also be traced back to Blastomyces helicus in the western U.S. and Blastomyces percursus in Africa.
Fig.1 Map of the estimated distribution of Blastomyces. (Pullen, M. F., et al., 2022)
Pathogenesis of Blastomycosis
Blastomycosis is contracted by breathing in fungal spores found in the surroundings. Within the lungs, these spores shift into the pathogenic yeast form, potentially disseminating through the bloodstream to other organs. Pulmonary complications are predominant, varying from mild, self-resolving instances to severe, life-threatening conditions like adult respiratory distress syndrome.
Fig.2 Characteristic Blastomyces microscopy. (Pullen, M. F., et al., 2022)
Vaccine and Therapeutics Development for Blastomycosis
Vaccine Development
Researchers have explored various approaches, including subunit vaccines, live-attenuated vaccines, and DNA vaccines, targeting different antigens (such as BAD-1) from Blastomyces dermatitidis.
Therapeutics Development
The mainstay of therapy for blastomycosis has been the use of antifungal medications, primarily the azole class of drugs including itraconazole and voriconazole, as well as amphotericin B.
Our Services
Our strengths lie in providing a one-stop solution for all aspects of research on blastomycosis, including access to cutting-edge technologies, a comprehensive service platform with disease models, vaccines, and therapeutic development, and a team of experienced professionals dedicated to advancing knowledge in this field.
Therapeutic Development Services of Blastomycosis
Vaccine Development of Blastomycosis
Infectious Disease Models
Our company provides various models of blastomycosis for you to gain a more comprehensive understanding of blastomycosis pathogenesis, host-pathogen interactions, and the development of effective diagnostic, preventive, and therapeutic strategies.
Pathogen Infection Models
Animals can be infected with Blastomyces dermatitidis spores or yeast cells, either through intranasal, intratracheal, or intravenous routes.
Optional Models: Mouse model of Blastomyces dermatitidis infection, etc.
Why Choose Us
Our strength lies in equipping researchers with the necessary tools and assistance to achieve advancements in comprehending and addressing blastomycosis. Our dedication to excellence and innovation distinguishes us as a frontrunner in blastomycosis research.
If you are interested in our service, do not hesitate to reach out to us for additional insights and detailed quotations about the specialized services we provide.
Reference
- Pullen, Matthew F et al. "Blastomycosis-Some Progress but Still Much to Learn." Journal of fungi (Basel, Switzerland) 8.8 (2022): 824.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
