Bartonellosis, or Carrión's disease, is a group of infectious diseases caused by bacteria of the genus Bartonella. As a leading research service provider in the field of infectious disease diagnostics, vaccine, and therapy development, our company has been at the forefront of combating Bartonellosis.
Overview of Bartonellosis
Bartonellosis, caused by various species of the Bartonella bacteria, encompasses a spectrum of diseases with diverse presentations. These include Carrión's disease, cat-scratch disease, trench fever, bacillary angiomatosis, peliosis hepatis, chronic lymphadenopathy, chronic bacteremia, endocarditis, and neurological disorders.
Bartonella species have developed various mechanisms to evade host immune responses, enabling chronic infection and disease progression. These bacteria can target different tissues, including red blood cells, lymph nodes, liver, and skin, resulting in diverse manifestations.
Fig. 1 Life cycle of Bartonella in the mammalian species. (Mada P. K., et al., 2023)
Vaccine Development for Bartonellosis
Proteins such as flagellin, Brps, IalB, FtsZ, and miscellaneous outer membrane proteins have emerged as potential targets for vaccine development. Flagellin, a subunit of the flagella, has shown promise in reducing erythrocyte infection. Brps, exhibiting structural similarities to trimeric autotransporter adhesion proteins (TAAs), may play a role in adhesion and immune evasion. IalB, involved in erythrocyte invasion, and FtsZ, a cell division protein, have also demonstrated strong immunogenicity and unique structural features.
Therapeutics Development for Bartonellosis
For the therapeutics of Bartonellosis, antimicrobial agents such as azithromycin, ciprofloxacin, gentamicin, trimethoprim-sulfamethoxazole, and rifampin have shown efficacy in reducing the duration of symptoms and improving outcomes. The choice of antimicrobial regimen depends on the presentation and severity of the disease.
| Bartonella disease |
Adults |
Children |
| Cat scratch disease |
No recommendation Azithromycin if extensive lymphadenopathy |
No recommendation Azithromycin if extensive lymphadenopathy |
| Carrion's disease (Oroya fever) |
Chloramphenicol + b-lactam or ciprofloxacin |
Chloramphenicol + b-lactam or ciprofloxacin or chloramphenicol or doxycycline + gentamicin |
| Carrion's disease (Verruga peruana) |
Doxycycline + gentamicin or streptomycin |
Rifampin |
| Trench fever and chronic bacteremia |
Doxycycline + gentamicin |
Unknown |
| Bacillary angiomatosis |
Erythromycin or doxycycline |
Erythromycin |
| Peliosis hepatis |
Erythromycin or doxycycline |
Erythromycin |
| Endocarditis |
Doxycycline + gentamicin or Ceftriaxone + gentamicin ± doxycycline |
Unknown |
Our Services
At our company, we offer comprehensive Bartonellosis vaccine and therapy development services tailored to meet the unique needs of our clients. Our team of experienced scientists and researchers work diligently to provide innovative solutions.
Infectious Disease Models
- B. elizabethae Infection
- B. tamiae Infection
- B. birtlesii Infection
- B. henselae Infection
- B. tribocorum Infection
- B. elizabethae Infection
Available Species: Swiss Webster, BALB/c, C57Bl/6, OF1, CD1, others
Our company offers a wide range of preclinical research services to support Bartonellosis vaccine and therapy development. This includes in vitro assays, animal studies, pharmacokinetic and pharmacodynamic evaluations, toxicology studies, and immunogenicity assessments. If our services have piqued your interest, we warmly welcome you to reach out to us for further information and obtain a detailed quotation for the services you require.
References
- Tahir A. H., et al. "Zoonotic importance of bartonellosis." Zoonosis, Unique Scientific Publishers, Faisalabad, Pakistan 4 (2023): 490-501.
- Mada Pradeep Kumar, Hassam Zulfiqar, and Andrew Stevenson Joel Chandranesan. "Bartonellosis." StatPearls [Internet]. StatPearls Publishing, 2023.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
