Antiparasitic drugs play a vital role in combating parasitic infections. Our company specializes in the research and development of cutting-edge antiparasitic drugs. Leveraging advanced technology and a proficient research team, we are well-equipped to assist you in identifying promising drug candidates targeting specific parasites while expediting the commercialization of your research.
What are Antiparasitic Drugs?
Antiparasitic drugs are a class of drugs specifically designed to combat infections caused by various parasites. For example, parasitic diseases caused by pathogens such as helminths, amoeba, parasitic fungi, and protozoa can all be treated using antiparasitic drugs.
Fig. 1 Mechanism of miltefosine in the treatment of Leishmania infection. (Dorlo T P C, et al., 2012)
How Do Antiparasitic Drugs Work in the Body?
The specific mechanism of action of antiparasitic drugs depends on the type of target parasite and the drug used. Here are some common ways in which antiparasitic drugs exert their effects:
Disruption of Metabolic Pathways
By targeting enzymes or metabolic pathways essential for parasite growth, antiparasitic drugs can effectively inhibit parasite replication and survival.
Alteration of Cellular Membrane Integrity
Certain antiparasitic drugs target the integrity and function of the parasite's cell membrane, thereby disrupting important cellular processes, leading to the death or elimination of the parasite.
Interference with DNA Synthesis
Some parasitic drugs disrupt the parasite's DNA replication or inhibit enzymes involved in DNA synthesis to hinder the parasite's ability to reproduce and thrive in the host.
Modulation of Neurotransmission
By interfering with neurotransmission or affecting specific receptors or ion channels, some parasite drugs can disrupt the parasite's ability to coordinate basic functions, leading to its paralysis or death.
Classic Drugs for Parasitic Infections
Many antiparasitic drugs have been approved after careful experimental and research evaluation. Some classic antiparasitic drugs are as follows:
| Antiparasitic Drugs |
Targets |
Mechanism |
Indications |
| Nitazoxanide |
Enzyme pyruvate |
Disruption of metabolic pathways |
Multiple parasitic infections, such as Cryptosporidium parvum, Giardia lamblia, and Entamoeba histolytica |
| Melarsoprol |
Melarsen oxide |
Disruption of metabolic pathways |
Trypanosoma brucei gambiense |
| Metronidazole |
DNA helix |
Interference with DNA synthesis and replication |
Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia |
| Tinidazole |
DNA helix |
Interference with DNA synthesis and replication |
Trichomonas vaginalis, Giardia lamblia, and Entamoeba histolytica |
| Albendazole |
β-tubulin subunit |
Disruption of metabolic pathways |
Roundworms, hookworms, whipworms, and tapeworms |
Our Services
The development of antiparasitic drugs has revolutionized the management of parasitic infections, offering effective treatment options. In line with our dedication to reducing the global burden of parasitic diseases, our company is actively engaged in supporting and contributing to the advancement of novel antiparasitic drugs. By collaborating with us, you will receive robust support to accelerate your research progress in the field of antiparasitic drug development.
Workflow of Antiparasitic Drug Development
Applicable Disease Types
- Amoebiasis
- Anisakiasis
- Ascariasis
- Taeniasis
- Toxoplasmosis
- Trichinosis
- Babesiosis
- Balantidiasis
- Blastocystosis
- Dientamoebiasis
- Diphyllobothriasis
- African Trypanosomiasis
- Fasciolopsiasis
- Filariasis
- Giardiasis
- Malaria
- Trichomoniasis
- And More
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Dorlo T P C, Balasegaram M, Beijnen J H, et al. Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis[J]. Journal of Antimicrobial Chemotherapy, 2012, 67(11): 2576-2597.
- Dziduch K, Greniuk D, Wujec M. The current directions of searching for antiparasitic drugs[J]. Molecules, 2022, 27(5): 1534.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
