Antibiotics have revolutionized the field of medicine, offering powerful tools in the fight against infectious diseases. With a dedicated team and advanced technologies, our company aims to develop innovative antibiotics that can overcome resistance mechanisms to revolutionize the field of infectious disease therapeutics.
What are Antibiotics?
Antibiotics are substances derived from living organisms or synthesized chemically, designed to combat bacterial infections. Antibiotics have revolutionized the field of medicine by providing effective therapeutic options for infectious diseases caused by bacteria. These drugs have played a crucial role in saving lives, preventing complications, and improving overall public health.
Fig. 1 Mechanisms of action of some antibiotics. (Aranda F L, Rivas B L., 2022)
How Do Antibiotics Work?
Antibiotics work through various mechanisms, targeting specific components or processes within bacteria to inhibit their growth or kill them outright.
Destroying Bacterial Cell Walls
The cell wall is a crucial component of bacterial cells, providing structural support and protecting them from external stresses. Antibiotics that target the cell wall interfere with its synthesis, leading to the weakening and eventual destruction of the bacterial cell.
Inhibiting Protein Synthesis
Proteins are essential for various critical functions within bacterial cells, including enzymatic reactions, structural integrity, and cellular processes. By targeting the bacterial ribosomes, antibiotics disrupt the protein synthesis and impede bacterial growth and survival.
Interfere with DNA Replication
DNA replication is a fundamental process in bacterial cells, allowing them to reproduce and multiply. Antibiotics that interfere with DNA replication disrupt this crucial step, preventing bacterial cells from dividing and propagating the infection.
Approved Antibiotics as Infectious Disease Therapeutics
| Antibiotics |
Mechanism |
Indications |
| Amoxicillin |
Inhibit bacterial cell wall synthesis |
Respiratory tract infections, urinary tract infections, and skin infections |
| Ceftriaxone |
Inhibit bacterial cell wall synthesis |
Severe respiratory tract infections, meningitis, and sexually transmitted infections |
| Azithromycin |
Inhibit protein synthesis |
Respiratory tract infections, skin and soft tissue infections, and genitourinary tract infections |
| Levofloxacin |
Inhibit DNA replication |
Respiratory tract infections, urinary tract infections, and skin and soft tissue infections |
Challenges in Antibiotic Development
Fig. 2 The mechanisms of antibiotic resistance in bacteria. (Mutuku C, et al., 2022)
Our Services
Our company recognizes the urgent need to address antibiotic resistance. Our dedicated team of scientists continually strives to stay one step ahead of resistant bacteria by employing innovative approaches and cutting-edge technologies. By staying at the forefront of research, we aim to develop antibiotics that overcome resistance mechanisms, prolonging the effectiveness of these life-saving drugs.
Workflow of Antibiotic Development
Target Identification
Our expert team utilizes advanced techniques to identify specific targets within bacteria that can be targeted to inhibit their growth or survival.
Hit Discovery
Hits are compounds that show initial activity against the target. By screening compound libraries, natural product screening, virtual screening and fragment-based drug discovery, we look for molecules or compounds that can interact with the identified target and potentially inhibit its activity.
Hit-to-Lead Transition
Medicinal chemistry techniques are used to iteratively modify the chemical structure of the hits, taking into account factors such as potency, selectivity, pharmacokinetics and safety. The goal of this step is to find lead compounds with higher potency, selectivity and other desirable properties.
Lead Optimization
This step involves further refining the selected lead compound to optimize its drug-like properties and enhance its efficacy. We perform extensive testing and analysis to optimize the pharmacokinetics, toxicology, pharmacodynamics and other relevant properties of the lead compound.
Antimicrobial Activity Screening
Antimicrobial activity screening involves conducting in vitro experiments using pathogens to evaluate the ability of lead compounds to inhibit the growth or kill target microorganisms. The tests include minimum inhibitory concentration (MIC) testing, minimum bactericidal concentration (MBC) testing, time-kill assays, and others.
Preclinical Studies
Using animal models infected with bacteria, our scientists conduct rigorous preclinical studies on lead compounds that exhibit favorable characteristics to evaluate their safety, efficacy, and pharmacokinetics.
Applicable Infectious Disease Types
At our company, we develop innovative antibiotics against a broad range of bacterial infections. Our goal is to advance the field of infectious disease therapeutic and management by providing effective solutions.
- Acinetobacter Infection
- Actinomycosis
- Bacillus Cereus Infection
- Bacteroides Infection
- Campylobacteriosis
- Carrion's Disease
- Diphtheria
- Ehrlichiosis
- Gas Gangrene
- Human Monocytic Ehrlichiosis
- Kingella Kingae Infection
- And More
If you are interested in our services, please feel free to contact us for more details and quotation information of related services.
References
- Aranda F L, Rivas B L. Removal of amoxicillin through different methods, emphasizing removal by biopolymers and its derivatives. An overview[J]. Journal of the Chilean Chemical Society, 2022, 67(3): 5643-5655.
- Mutuku C, Gazdag Z, Melegh S. Occurrence of antibiotics and bacterial resistance genes in wastewater: resistance mechanisms and antimicrobial resistance control approaches[J]. World Journal of Microbiology and Biotechnology, 2022, 38(9): 152.
All of our services and products are intended for preclinical research use
only and cannot be used to diagnose, treat or manage patients.
